White saffron (Curcuma mangga Val.) attenuates diabetes and improves pancreatic β-cell regeneration in streptozotocin-induced diabetic rats

Pujimulyani, Dwiyati and Yulianto, Wisnu Adi and Setyowati, Astuti and Prastyo, Prastyo and Windrayahya, Sulkhan and Maruf, Ali (2022) White saffron (Curcuma mangga Val.) attenuates diabetes and improves pancreatic β-cell regeneration in streptozotocin-induced diabetic rats. Elsevier.

[thumbnail of Similarity Artikel] Text (Similarity Artikel)
2. White saffron Penulis 2 Safron vs diabetes Q1Toxicologi Reports 2022.pdf.pdf

Download (6MB)

Abstract

A B S T R A C T
Diabetes is a chronic disease caused by an imbalance of insulin release to the bloodstream in response to
excessive glucose influx, which causes hyperglycemia. White saffron (Curcuma mangga Val.), an Indonesian aromatic
spice, contains essential phytochemicals and has a number of potential health benefits. Here, we
examined the effects of oral administration of white saffron powder (WSP): 1.5 and 4.5 g (WSP 1.5 and WSP 4.5)
in streptozotocin (STZ)-induced diabetic rats. WSP was administered orally on a daily basis for one month and its
antidiabetic, anti-inflammatory, and antioxidative effects were investigated by measuring the concentrations of
blood glucose, insulin, interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin 8 (IL-8), malondialdehyde
(MDA), and superoxide dismutase (SOD) activity. In response to high WSP intervention (WSP 4.5), treated
rats showed increased insulin level and SOD activity and reduced blood glucose, IL-6, IL-8, TNF-α, and MDA
levels, which were closely related to the positive control (PC) group. In addition, Hematoxylin and Eosin (H&E)
staining of the pancreatic tissues showed that WSP 4.5-treated rats had significant improvement in β-cell
regeneration, which taken together reflected the antidiabetic potential of Curcuma mangga Val.

Item Type: Article
Subjects: A General Works > AC Collections. Series. Collected works
Divisions: Fakultas Agroindustri > Program Studi Teknologi Hasil Pertanian
Depositing User: THP UMBY
Date Deposited: 27 Mar 2023 07:36
Last Modified: 27 Mar 2023 07:36
URI: http://eprints.mercubuana-yogya.ac.id/id/eprint/18685

Actions (login required)

View Item
View Item